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Serum Bile Acid Profiling For Inflammatory Bowel Disease Characterization
Based on serum bank material, BA profiling was applied in IBD patients and healthy controls which showed that most but not all BA species were decreased to a different extent in CD and UC. BA decreases were highly pronounced in CD patients with surgical interventions in the gut. On the other hand, UC patients with additional liver and gallbladder diseases showed clearly increased levels of those BAs that are synthesized directly in the liver (primary BAs), or subsequently modified by intestinal bacteria (secondary BAs). Furthermore, a marked decrease in the toxic BA lithocholic acid (LCA) was found together with a marked increase in its physiological detoxification product, hyodeoxycholic acid (HDCA), irrespective of the IBD phenotype or clinical manifestation, which showed accelerated detoxification activity in IBD patients. Thus, serum BA profiling might serve as an additional diagnostic tool for IBD characterization and differentiation. In combination with expression profiles of nuclear pregnane X receptor (PXR)-regulated genes, it might allow us to estimate the BA detoxification potential of IBD patients.

Government Of Canada Acts To Protect Newborns And Infants From Bisphenol A In Polycarbonate Plastic Baby Bottles
The Government of Canada is moving forward with proposed regulations to prohibit the advertisement, sale and importation of polycarbonate plastic baby bottles that contain bisphenol A, otherwise known as BPA, to reduce newborn and infant exposure to this substance, announced the Honourable Leona Aglukkaq, Minister of Health.
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Ascenta Therapeutics Announces Multiple Presentations On AT-101 At 2009 ASCO Annual Meeting
Ascenta Therapeutics announced that eleven presentations or publications on pre-clinical and clinical studies of AT-101, an oral, pan-Bcl-2 inhibitor, in several major tumor types will be made during the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting, May 29-June 2, in Orlando, Florida.
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BIO Applauds Selection Of Francis Collins To Lead NIH

Biotechnology Industry Organization (BIO) President and CEO Jim Greenwood issued the following statement today praising President Barack Obama"s nomination of Francis S. Collins as Director of the National Institutes of Health (NIH): "BIO and its member companies applaud President Barack Obama for his nomination of Dr. Francis S. Collins as Director of the NIH and urge the Senate to move quickly to confirm him. "Dr. Collins brings impeccable credentials and experience to the position. He is a strong candidate to oversee the primary federal government agency charged with conducting and supporting medical research.A recipient of the Biotechnology Heritage award in 2001, Dr. Collins played a key role in the sequencing of the human genome which has opened up virtually limitless possibilities for science and technology. "As Director of the National Human Genome Research Institute, he initiated research projects and collaborated with scientists around the world to further increase our knowledge of the human genome and the genetic causes of disease. "His vast experience with government agencies combined with his unparalleled scientific expertise make Dr. Collins an outstanding advocate for the NIH. His experience, expertise and leadership are critical as the Institutes move to conduct the basic research required to meet President Obama"s challenge to defeat cancer in our time and to address the myriad debilitating diseases devastating millions of patients worldwide. "BIO and its member companies are committed to expanding the boundaries of science by discovering, developing and delivering innovative therapies to patients including the millions of patients around the world who suffer from diseases for which there is no treatment or cure. We look forward to working with Dr. Collins and the dedicated staff of the NIH to attain the President"s visionary goal of finding a cure for cancer "within our time."" BIO


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