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AVEO's Tivozanib Demonstrates Anti-Tumor Activity In Engineered Lung Tumors Exhibiting Treatment Resistant Mutations
AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced data which demonstrates that tivozanib (AV-951) - the company"s oral, triple VEGF receptor inhibitor - exhibits potent anti-angiogenic and anti-tumor activity in AVEO"s proprietary in vivo lung cancer models. Specifically, treatment with tivozanib resulted in complete tumor growth inhibition or tumor regression (shrinkage) in lung tumors driven by EGFR or KRAS mutations, which are especially difficult to treat. These data are being presented today at the 13th World Conference on Lung Cancer (WCLC) in San Francisco, abstract number PD10.1.5.

Plastics Chemical Retards Growth, Function Of Adult Reproductive Cells
Bisphenol A, a chemical widely used in plastics and known to cause reproductive problems in the offspring of pregnant mice exposed to it, also has been found to retard the growth of follicles of adult mice and hinder their production of steroid hormones, researchers report.
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Newborn Brain Cells Show The Way
Although the fact that we generate new brain cells throughout life is no longer disputed, their purpose has been the topic of much debate. Now, an international collaboration of researchers made a big leap forward in understanding what all these newborn neurons might actually do. Their study, published in the July 10, 2009, issue of the journal Science, illustrates how these young cells improve our ability to navigate our environment.
Public Health

California Gov. Schwarzenegger's State Budget Plan Includes Cuts To County HIV/AIDS Services

The Santa Maria Times examines how California Gov. Arnold Schwarzenegger"s (R) plan to reduce state spending by more than $5 billion over the next two fiscal years, which includes millions of dollars in funding cuts to HIV prevention, education and treatment programs, could affect county residents (Womack, Santa Maria Times, 5/31). According to the Times, hundreds of residents in Santa Barbara County -- including more than 100 AIDS Drug Assistance Program (ADAP) clients -- would potentially be affected by the funding cuts (Santa Maria Times, 5/31). The proposal also would result in $1.8 million in cuts to programs for low-income residents living with HIV in Riverside County, the Desert Sun reports (Brambila, Desert Sun, 5/29). The plan, issued by Schwarzenegger last week, includes $55.5 million in cuts to California"s ADAP and other state Office of AIDS programs (Kaiser Daily HIV/AIDS Report, 5/27). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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