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DNA Helps Reunite Children With Their Families
Of the 600,000-800,000 people trafficked across international borders each year, 50 percent are under 17. It is estimated that by 2010, human trafficking will be the No. 1 crime worldwide.

Human Genome Sciences And GlaxoSmithKline Announce Positive Phase 3 Study Results For BENLYSTA(TM) In Systemic Lupus Erythematosus
Human Genome Sciences, Inc. (Nasdaq: HGSI) and GlaxoSmithKline PLC (GSK) announced that BENLYSTA(TM) (belimumab, formerly LymphoStat-B(R)) met the primary endpoint in BLISS-52, the first of two pivotal Phase 3 trials in patients with serologically active systemic lupus erythematosus (SLE). In the placebo-controlled BLISS-52 study, the results showed that belimumab plus standard of care achieved a clinically and statistically significant improvement in patient response rate at Week 52, compared with standard of care alone. Study results also showed that belimumab was generally well tolerated, with adverse event rates comparable between belimumab and placebo treatment groups.
News of the day
Rep. Pitts To Offer Amendment Excluding Abortion Coverage From House Health Care Bill
Rep. Joe Pitts (R-Pa.) said he plans to introduce an amendment to the House health care overhaul bill (HR 3200) that would prohibit insurers from being required to cover abortion, unless the woman"s life is at risk or the pregnancy is a result of rape or incest, CQ Today reports. Pitts said he will offer the amendment Thursday at the first House Energy and Commerce Committee mark-up session.The House bill would authorize the Obama administration to craft minimum benefit standards for health insurance plans, CQ Today reports. President Obama has said that he considers reproductive health care an essential service. Democrats say Republicans are trying to expand the Hyde amendment"s exclusion on using federal Medicaid funding to cover abortion to all health care services. Rep. Diana DeGette (D-Colo.), vice chair of the Energy and Commerce Committee, said, "I think that if anti-choice Republicans or others see this as an opportunity to expand prohibitions on a legally allowed and medically appropriate practice, then they are wrong." She added, "We are not going to use the health care bill to expand prohibitions on a legal medical practice, period." Pitts, Rep. Christopher Smith (R-N.J.) and other supporters of the amendment say it is necessary to block the administration from requiring abortion coverage. The committee has blocked three of Smith"s abortion-related amendments so far this year (Wayne, CQ Today, 7/15).
Oncology

Can Tribble 3 Can Induce Non-Alcoholic Fatty Liver Disease?

Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance. This research, lead by Dr. Yu-Gang Wang and his colleagues in the Department of Gastroenterology, Shanghai Changning Central Hospital, China, used real-time fluorescent quantitative reverse transcription-polymerase chain reaction technology and Western blotting analysis to study the protein expression of TRB3mRNA, Akt and phosphorylation protein kinase B during the progression of NAFLD. The expression level of TRB3mRNA in NAFLD rats was significantly higher than in normal controls. Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD. This study provides an experimental basis for future studies on the role of TRB3 in NAFLD. The control of the expression level of TRB3 in liver may become a new target for NAFLD therapy. Reference: Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2009; 15(19): 2329-2335 Correspondence to: Dr. Xi-Mei Chen, Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China. Jian-Xia Cheng World Journal of Gastroenterology


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