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Plexxikon Announces PLX4032 Phase 1 Data Showing Objective Responses In Metastatic Melanoma Patients
Plexxikon Inc. today announced preliminary data from a Phase 1 clinical study investigating PLX4032 (R7204). PLX4032 is a novel, oral and highly selective drug that targets the BRAFV600E cancer-causing mutation that occurs in most melanomas and about eight percent of all solid tumors. In patients whose cancer harbors this mutation and who were treated with therapeutic doses of PLX4032, tumor shrinkage and extended progression-free survival have been observed. Currently, two extension studies are being conducted in mutation-positive melanoma and colorectal cancer patients. Following the initial positive findings announced today, larger clinical trials to support a registration program for product approval are targeted to start later in 2009. Plexxikon and Roche are co-developing PLX4032 under their 2006 license and collaboration agreement.

Brain Neural Circuit Formation Requires Identification Of A Key Molecular Pathway
The research group of Dr. Frçİdçİric Charron, a researcher at the Institut de recherches cliniques de Montrçİal (IRCM), has made a discovery which could help treat spinal cord injuries and neurodegenerative diseases. This new finding has been published in the current issue of the prestigious scientific journal Neuron. Patricia T. Yam, Sçİbastien D. Langlois and Steves Morin, all at the IRCM, are listed as co-authors.
News of the day
Increased Fighting Makes Humanitarian Work, Health Situation More Difficult In Somalia, U.N. Says
Despite increasing danger posed by "al Qaeda-linked militants," U.N. Emergency Relief Coordinator John Holmes said Tuesday U.N. aid workers "were not backing away" from the country, Reuters reports. "Intense fighting is making it increasingly difficult to deliver aid in the Horn of Africa country, where U.N. agencies are trying to combat cholera outbreaks and maintain food supplies to 3.5 million hungry people," the news service writes (Nebehay, 7/21).
Mental Health

Corrie's Vera Duckworth Meets Health Secretary Andy Burnham MP To Discuss Living With COPD, UK

British Lung Foundation celebrity ambassador and ex Coronation Street actress Liz Dawn met Health Secretary Andy Burnham MP at the NHS Innovations Expo. Liz encouraged Andy Burnham MP to have a lung test and talked to him about living with the lung disease COPD. Health minister Lord Darzi and David Nicholson, Chief Executive of the NHS, also met with Liz and were given a lung test by a BLF specialist nurse. Liz is heading up the BLF"s "Love Your Lungs" campaign during Breathe Easy Week (15th-21st June). Liz herself has the lung disease Chronic Obstructive Pulmonary Disease (COPD) and will be talking about her experiences of living with the disease. COPD is an umbrella term for a group of lung conditions including emphysema and chronic bronchitis, and is currently the fifth biggest killer in UK. Liz Dawn, BLF Celebrity Ambassador says "It was great to have the opportunity to talk to Andy Burnham MP, Lord Darzi and David Nicholson. I encouraged them all to have a lung test and talked to them about the importance of early diagnosis and that lung testing should be included in the Government"s new Health MOT". Dame Helena Shovelton, Chief Executive of the British Lung Foundation said, "With the National Strategy for COPD due later this year, it is fantastic to have the "queen of soaps" Liz Dawn as our celebrity ambassador. We really appreciate what Liz has done for the charity this week raising the profile of COPD in the media and talking about living with a lung condition." The British Lung Foundation


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