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Final Analysis Shows HPV Vaccine Highly Effective At Preventing Precancerous Cervical Lesions
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U.S. Doubles Annual Malawi HIV/AIDS Support To $45M
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Environmental Factors Instruct Lineage Choice Of Blood Progenitor Cells
The research team led by Dr. Timm Schroeder, stem cell researcher at Helmholtz Zentrum MÃønchen, has developed a new bioimaging method for observing the differentiation of hematopoietic progenitor cells (HPC) at the single-cell level. With this method the researchers were able to prove for the first time that not only cell-intrinsic mechanisms, but also external environmental factors such as growth factors can control HPC lineage choice directly. The findings, published in the current issue of the prestigious journal Science, provide an essential building block for understanding the molecular mechanisms of hematopoiesis and are an important prerequisite for optimizing therapeutic stem cell applications.
Cardiovascular

Health Warning After Lancashire Workers Catch Legionnaires' Disease, UK

The Health and Safety Executive (HSE) has warned companies in Lancashire to ensure they carry out regular, simple checks to protect employees from Legionnaires" disease. The warning follows the prosecution of butchery processing company Kepak UK Ltd after two employees caught the disease at Kepak"s Carr Place premises on the Walton Summit Industrial Estate, Bamber Bridge, Preston. The company, which has its headquarters on Flanshaw Lane in Wakefield, was fined ÷£25,000 and ordered to pay ÷£20,000 in costs at Preston Crown Court on Monday 27 July. Kepak pleaded guilty to breaching Section 2(1) of the Health and Safety at Work etc Act 1974 by failing to protect its employees from the risk of contracting Legionnaires" disease. The court heard that the first case of Legionnaires" disease was diagnosed on 26 September 2006 in Boguslaw Plociennik, who was employed as a boner, and a second on 3 October 2006 in Zbigniew Rauk, who was employed as a packer. Following notification of the two cases, an outbreak committee was formed made up of HSE, South Ribble Borough Council"s Environmental Health Department, Central Lancashire Primary Care Trust, the Health Protection Unit and Lancashire Teaching Hospitals. Water samples were taken throughout the building and significant levels of legionella were found to be present at three locations: a pressure washer hose point, an apron wash shower point, and a pressure washer header tank. The tank was fed by hot and cold water and supplied water to three pressure washer hose points in and around the process area. Employees used the pressure washer system to clean away meat and fat debris in the various processing areas as and when required. While the investigation was taking place, Kepak closed the Carr Place site and the domestic water system was drained, pumped through, chlorinated and disinfected. Kepak has subsequently not reopened the site, which was one of two the company operated in the Preston area. HSE Principal Inspector Dorothy Shaw said: "Kepak failed to carry out simple checks on the hot and cold water system. As a result, many of its employees working at the site were potentially exposed to the legionella bacteria, and two individuals were made seriously ill. "Any system containing water at temperatures between 20 and 45 degrees Celsius, and which may release an aerosol during operation or maintenance, is at risk of exposure to legionella bacteria. "Legionnaires" disease is a potentially fatal illness and, had the correct procedures been in place, the outbreak at Kepak"s premises would not have occurred. Legionella bacteria can build up in purpose-built water systems and, if conditions are favourable, the bacteria can multiply, increasing the risk. "A risk assessment had been carried out in May 2001 which set out that simple and periodic checks should be carried out on Kepak"s domestic water system, and that the control measures should be monitored and reviewed. But this did not happen." Notes Section 2(1) of the Health & Safety at Work etc Act 1974 states: "It shall be the duty of every employer to ensure, so far as is reasonably practicable, the health, safety and welfare at work of all his employees." HSE


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