Popular Articles

Dental Health Advocates Want To Sink Teeth Into Health Care Reform
The Washington Post reports many oral health professionals worry that dental issues have "a tenuous place at best in the national debate" regarding an overhaul of the health care system. Still, they emphasize that dental health is an integral part of health care and note the special burden untreated dental issues have on poor children. The paper also notes that "closing the gap between the worlds of dental care and medical care, with their separate histories and cultures, and their separate finance and delivery systems would be a formidable task."

"Jumping Gene" Diminishes The Effect Of A New Type 2 Diabetes Risk Gene
Research led by the German Institute of Human Nutrition (DIfE) has identified a new gene associated with diabetes, together with a mechanism that makes obese mice less susceptible to diabetes. A genomic fragment that occurs naturally in some mouse strains diminishes the activity of the risk gene Zfp69. The researchers also found that the corresponding human gene (ZNF642) is especially active in overweight individuals with diabetes. The results of the study, which also involved scientists from the University of Leipzig and the German Cancer Research Center in Heidelberg, are published July 3 in the open-access journal PLoS Genetics.
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Association of American Medical Colleges Supports Hospital Agreement On Health Care Reform
AAMC (Association of American Medical Colleges) President and CEO Darrell G. Kirch, M.D., issued the following statement on the agreement reached by the hospital community, the Obama administration, and the Senate Finance Committee in support of health care reform:
Public Health

JAMA Study: Effectively Managing Pain With Depression

Pain, the most common reason for adults to visit a primary care physician, and depression, the most frequent mental complaint requiring a doctor"s appointment, occur together as often as half the time. Researchers from the Indiana University School of Medicine and the Regenstrief Institute report in the May 27 issue of the Journal of the American Medical Association (JAMA) that a strategy they developed of closely monitored antidepressant therapy coupled with pain self-management can produce substantial improvements in both depression and pain. "Treating depression these days is like treating high blood pressure. There are many effective drugs out there. To control high blood pressure, the physician closely monitors the patient to determine the most appropriate drug and the proper dosage. Often with depression treatment, the patient is prescribed one of the many effective antidepressants but is not closely followed to see if it"s the best choice and the proper dosage, which means the patient"s depression is not being effectively managed," said the study"s principal investigator, Kurt Kroenke, M.D., professor of medicine at the IU School of Medicine and a Regenstrief investigator. "There are more significant challenges in treating patients with persistent pain. Ironically research on effective pain treatment has lagged a couple of decades behind work on depression and the drug choices are not as good. More study on the basic science and clinical levels needs to be done on both pain and the link between pain and depression, which may share common biological pathways, to develop better options," said Dr. Kroenke, an Indiana University-Purdue University Indianapolis Chancellor"s Professor. The 250 individuals in the JAMA study had low back, hip, or knee pain for three months or longer and at least moderate depression. They were randomized into two groups. The control group of 127 received usual care from their internists for both depression and pain. The other 123 received careful monitoring of the medications prescribed for their depression plus 12 weeks of pain self-management training. This training included muscle relaxation and deep breathing exercises as well as coping, distraction and other tactics. Those whose depression medications were closely monitored and who were trained in pain self- management were two to three times more likely to have decreased depression than those in the control group. Pain severity and disability also lessened. These benefits continued for the six months after optimizing antidepressant therapy and pain self-management had been completed. "We were pleased to see the patients whose anti-depressants were closely monitored and who practiced self-management improved, but we think we can lessen pain and depression even more. In our next studies we plan to investigate cognitive behavioral therapy as well as optimizing pain medications to see if even greater improvements in pain can be achieved. Because pain and depression are among the leading causes of decreased work productivity, a strategy that is effective for both should be attractive not only to patients and their physicians. Health insurers and the business community will be interested as well," said Dr. Kroenke, an internist who is a former president of the Society of General Internal Medicine. In addition to Dr. Kroenke, co-authors of "Optimized Antidepressant Therapy and Pain Self-management in Primary Care Patients with Depression and Musculoskeletal Pain A Randomized Controlled Trial" are Matthew J. Bair, M.D., Teresa M. Damush, Ph.D., and Wanzhu Tu, Ph.D., of the IU School of Medicine and the Regenstrief Institute; Jingwei Wu, M.S., of the IU School of Medicine; Shawn Hoke, B.A. of the Regenstrief Institute; and Jason Sutherland, Ph.D., formerly of the Regenstrief Institute. Dr. Bair and Dr. Damush also are affiliated with the Richard Roudebush Veterans Affairs Medical Center. The study was funded by the National Institute of Mental Health. Indiana University School of Medicine


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