Categories
Cardiovascular
Diagnostics
Endocrinology
Health Insurance
Medical Devices
Mental Health
Nutrition
Oncology
Public Health
Sexual Health
Popular Articles

Prostate Cancer Gene 3 (PCA3): Development And Internal Validation Of A Novel Biopsy Nomogram
UroToday.com - In this paper, we investigated 809 prostate cancer patients subjected to >10 cores at initial or repeat prostate biopsy from two prospective, multi-center studies from Europe and North America It has been demonstrated that the urinary marker Prostate CAncer gene 3 (PCA3) represents a novel prostate cancer (PCa) detection marker capable of increasing accuracy of multivariable biopsy nomograms.[1] The paper reports the first PCA3-based nomograms which accurately identify individuals at risk of harboring PCa (AUC=0.73). If a PCA3 score in combination with established risk factors is available, this novel tool assists clinicians in deciding whether further prostatic evaluation is necessary.

Buprenorphine-naloxone A Helpful Addition To Opioid Substitution Treatment, Australia
People who inject drugs may be less likely to inject buprenorphine-naloxone than other opioid substitutes, according to the results of a recent study published in the Medical Journal of Australia.
News of the day
Oregon Department Of Human Services Selects APS Healthcare To Manage Expanded Statewide Medicaid Program
APS Healthcare, a leading provider of specialty healthcare solutions, has been selected by the Oregon Department of Human Services (DHS), Division of Medical Assistance Programs, to manage its statewide Medicaid disease and medical care management programs. The integrated program will assist Oregon"s Medicaid and SCHIP fee-for-service clients to access healthcare, minimize catastrophic health events and improve health outcomes through education and interventions that help promote behavior change.
Oncology

New Imaging Technique: Toward Spinal Cord Regeneration?

The axon is a part of the neuron through which nerve impulses are transmitted, and at the end of which is located the synapse, which connects it to another neuron. In the event of a lesion, the axon is the component which must be regenerated in order to restore the connections between the different neurons and re-form the nerve. The regeneration capacity of axons within the central nervous system, of which the spinal cord is part, has until now been much debated. Axons can regenerate toward the muscles, whereas in the opposite direction inhibiting factors prevent regrowth toward the nerve centers. The observation made by Geneviç¨ve Rougon"s team at IBDML shows that the axons also regrow in the direction of the spinal cord within a short lapse of time after the injury. Moreover, this regrowth is encouraged by post-traumatic angiogenesis, in other words by the process of formation of new blood vessels in the damaged tissue. After injury to a mouse"s spinal cord, extensive and extremely active angiogenesis is observed, peaking in intensity one week after the lesion. At the same time, regrowth of the axons takes place preferentially and more rapidly in the vicinity of the blood vessels. These observations suggest that stimulating and prolonging angiogenesis could open up new prospects for treatment and encourage functional recovery after, for instance, lesion of the spinal cord. This spatio-temporal interaction was described by combining two new techniques in imaging: the use of mice whose cell populations can be observed thanks to their fluorescent properties, and 2-photon microscopy. This new imaging protocol makes it possible to display in situ and in 3D the cell phenomena that come into play under traumatic or pathological conditions, and to characterize their dynamics by means of repeated observations of the same mouse. In this way, cell interactions can be described dynamically, over space and time, in a live animal, something that is impossible to do with conventional histology (1) techniques, which require the sacrifice of several animals at each relevant stage. This non-invasive technique drastically reduces the number of mice used and, since the experiment can be reproduced using the same animal, considerably improves the result. In addition to its importance for fundamental research, such a combination opens up new prospects for preclinical research. In the field of pharmacology, for instance, this kind of dynamic imaging could make it possible to precisely define application protocols for medicines, and better control their effects and adjust dosage. (1) Histology is the branch of biology which studies tissue. CNRS (Dç©lç©gation Paris Michel-Ange)


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):

© Copyright 2009