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Multiple Myeloma Research Consortium (MMRC) Activates Clinical Trials 30-40 Percent Faster Than Industry Standard
The Multiple Myeloma Research Consortium (MMRC), an innovative research model comprised of a network of 15 academic Member Institutions across North America and leadership in Norwalk, Connecticut, announced preliminary data from an analysis showing that clinical trials opened through its clinical trials network were activated 30 to 40 percent faster than comparable clinical trials in oncology. Based on the implementation of specific business solutions, particularly scientific leadership, standardized clinical contracts and on-site project management res, the MMRC has been able to decrease by an average of 100 days the time from the development and finalization of the trial"s protocol to actual patient enrollment.

Researchers Discover Key To Malaria Susceptibility In Children
A team of researchers from Case Western Reserve University School of Medicine have solved the mystery of why some children are more susceptible to malaria infection and anemia. These novel findings suggest that some children who are exposed to Plasmodium falciparum (P. falciparum) malaria before birth become tolerant to the malaria parasites, or their soluble products. This tolerance, which persists into childhood, reduces the ability of the immune system to attack and destroy parasites and increases the susceptibility of these children to develop a malaria infection. It also increases their risk for anemia. The study, published in this week"s issue of the open access journal, PLoS Medicine, is led by Indu Malhotra, Ph.D., and Christopher King, M.D., Ph.D., professor of international health, medicine, and pathology, with their colleagues at the Center for Global Health and Diseases at the Case Western Reserve University School of Medicine and their Kenyan colleagues at the Kenya Medical Research Institute and Division of Vector Borne Diseases.
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Teenagers - Find Out If You're Healthy, Online Quiz
A free, online lifestyle self-assessment service to help teenagers improve their health and wellbeing is being rolled out nationally by the Department of Health today.
Diagnostics

Osteoarthritis A Major Consequence Of Obesity Epidemic, Claims Charity In New Report

Obese people are four times as likely to develop osteoarthritis of the knee as they are to develop high blood pressure or type-2 diabetes, according to a leading arthritis charity, launching a new online report on the subject. But whereas high blood pressure and diabetes may be substantially improved on losing weight and are relatively easy to control with therapy, the changes resulting from osteoarthritis are irreversible, as worn cartilage cannot currently be repaired. However, according to Professor Alan Silman, medical director of the Arthritis Research Campaign, there is good news for the obese and overweight whose knees become painful due to osteoarthritis as a result of their weight. "Research shows that losing weight, however modest, when combined with exercise, is a panacea at every stage," said Professor Silman. "Achieving a healthy weight reduces the risk of developing the disease in the first place, relieves existing symptoms and helps to prevent further deterioration. And weight loss and exercise has been shown to achieve the same level of symptom relief as joint replacement surgery." The medical research charity is concerned that while rising rates of obesity have been linked to a number of serious disorders and health concerns, the risk of potentially crippling osteoarthritis have been, if not ignored, then certainly under-estimated. The true impact of obesity in the development of knee osteoarthritis has only recently become clear, said the charity, pointing to a study which revealed that at the most extreme, very obese people with a body mass index of 36 or more have a 14-fold higher risk of knee osteoarthritis compared to those in the healthy BMI range. Professor Silman warned there was a real concern that unless rocketing rates of obesity were tackled, the numbers of people needing joint replacement surgery would soar, which would have a considerable impact on the NHS. "There are two major risk factors for developing osteoarthritis - ageing and obesity - and as both these factors are on the rise in the UK, it"s an obvious prediction to make that the outcome could be a massive cost to the health service," he added. Joint replacements are more likely to fail earlier in obese patients, and the heavier the patients the less likely it is that surgery will bring about an improvement in symptoms. Very obese women are 19 times more likely to need knee replacement and four times more likely to need hip replacement surgery compared to women of a healthy weight. A series of studies have shown that even modest weight loss and exercise can help to reduce not only pain but also mobility and the ability to perform everyday activities. Professor Silman"s comments follow the publication of the charity"s online report, Osteoarthritis and obesity, which warns the public of the hitherto little publicised dangers to their health and quality of life of obesity on their joints. The Arthritis Research Campaign"s report, Osteoarthritis and obesity, can be accessed on its website at http://www.arc.org.uk from July 15. Arthritis Research Campaign


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