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The Automation Partnership's First Project To Automate Manufacture Of 3D Tissue Constructs
The Automation Partnership (TAP), a world leader in the design and development of innovative advanced automation for life science applications, announced it is collaborating with world leading academics on the prestigious, Technology Strategy Board funded, RAFT (Rapid Automated Fabrication of Tissues) Project to develop and commercialise novel technology for rapid production of 3D tissues, which have the potential to transform drug discovery and regenerative medicine.

GOP Leader McConnell Says 'Too Early To Know' About Sotomayor Filibuster
Senate Minority Leader Mitch McConnell (R-Ky.) on Friday said it is "way too early to know" whether Senate Republicans will attempt to filibuster the nomination of Judge Sonia Sotomayor, President Obama"s nominee for the Supreme Court, the AP/Minneapolis Star Tribune reports. Although other Senate Republicans have said that they do not plan to filibuster a vote on Sotomayor, McConnell said that Senate Democrats established a precedent of filibustering former President George W. Bush"s nominees. However, he added that he believes blocking votes on judges is generally a "bad idea." Senate Judiciary Committee ranking member Jeff Sessions (R-Ala.) has said a filibuster is unlikely, and Sen. John Cornyn (R-Texas) has said that Republicans do not have the votes or the desire to mount a filibuster against Sotomayor. Senate Democrats hope to have confirmation hearings for Sotomayor in July, followed by a full Senate vote before the August recess. Senate Republicans are hoping to push back the hearings until September to give them more time to review her judicial record.Antiabortion Groups Circulate 1998 Legal Brief Abortion-rights opponents on Friday circulated a 1998 legal brief supporting abortion rights that the Puerto Rican Legal Defense and Education Fund joined while Sotomayor was on the fund"s board. The brief -- which was submitted to the Supreme Court to support a challenge to a Missouri law that made it illegal to use public facilities for abortion services -- warned of "the danger of tampering with the core framework of Roe v. Wade." The brief added that the law would disproportionately affect poor women of color. According to the AP/Star Tribune, there is nothing to indicate that Sotomayor had any role in drafting the brief.PRLDEF President Cesar Perales said that although its board helps determine which legal issues the organization should focus on, it is not involved with deciding which cases to take on. Charmaine Yoest of Americans United for Life said, "That specific case makes it very difficult for [Sotomayor] to say that she doesn"t have a position" on abortion rights (Hirschfeld Davis, AP/Minneapolis Star Tribune, 6/5).Senate Judiciary Committee Approves Two Federal Judges In related news, the Senate Judiciary Committee on Thursday voted to approve two of Obama"s federal judge nominees, Roll Call reports. The committee voted 12-7 to approve David Hamilton to fill a vacancy in the 7th U.S. Circuit Court of Appeals and voted 16-3 to approve Andre Davis to fill a vacancy on the 4th Circuit Court of Appeals. The votes were delayed two weeks because of requests from panel Republicans. This week, the committee will consider the nomination of Judge Gerard Lynch to fill a vacancy on the 2nd U.S. Circuit Court of Appeals (Brady, Roll Call, 6/4).
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Gene Discovery Suggests Cancer Drugs Might Treat Alcoholism
A class of drugs already approved as cancer treatments might also help to beat alcohol addiction. That"s the conclusion of a discovery in flies of a gene, dubbed happyhour, that has an important and previously unknown role in controlling the insects" response to alcohol.
Public Health

Reducing Gasoline Emissions Will Benefit Human Health

President Barack Obama and Energy Secretary Steve Chu are consistent in their message that when it comes to transportation fuels, carbon-neutral biofuels as an alternative to gasoline are coming. While the focus of a shift from gasoline to biofuels has been on global warming, such a shift could also impact human health. A grant from the Energy Biosciences Institute (EBI) has produced a novel and comprehensive "Life Cycle Impact Assessment" to measure the benefits on human health that might result from a switch to biofuels. Although there are a number of uncertainties that must be addressed for a more accurate picture, these early results show that a biofuel eliminating even 10-percent of current gasoline pollutant emissions would have a substantial impact on human health in this country, especially in urban areas. "While the successful deployment of biofuels requires research to overcome technical barriers, there are other barriers that can often impose constraints more challenging than those related to technical feasibility, including constraints imposed by health risks," says Thomas McKone, an expert on health risk assessments who holds a joint appointment with Berkeley Lab"s Environmental Energy Technologies Division and the University of California Berkeley"s School of Public Health. "Just think, if we had done a life cycle impact assessment on the human health effects of gasoline years ago we might not be in the situation we"re facing today." McKone is the co-leader of EBI"s Life-Cycle Environmental and Economic Decision-Making for Alternative Biofuels programs with Arpad Horvath, an associate professor of civil and environmental engineering at UC Berkeley. At the recent 31st Symposium on Biotechnology for Fuels and Chemicals, conducted by the Society for Industrial Microbiology and held in San Francisco, he described a biofuels Life Cycle Impact Assessment (LCIA) that he carried out in collaboration with Agnes Lobscheid, an environmental scientist who also holds joint appointments with Berkeley Lab and UC Berkeley. "In a typical LCIA, we evaluate the potential impact on human health and the environment of a product or activity holistically, by analyzing those effects over the entire life cycle of the product or activity," McKone said in his presentation. "For biofuels, we will ultimately need to look at the overall human health and environmental impacts of biomass production, converting and processing this biomass into fuel, storing, transporting and distributing that fuel, and finally the actual combustion and use of the biofuel." EBI is a partnership between UC Berkeley, Berkeley Lab, the University of Illinois and BP, the energy corporation that has provided EBI with a 10-year $500-million grant. Part of its mission is to look into the environmental, social and economic dimensions of a transition to biofuels for transportation energy. In their initial LCIA, McKone and Lobscheid wanted to gain a better understanding of both life-cycle impacts and the distribution in space and time of these impacts for reduced gasoline use. To do this they first needed to define the factors that really matter for characterizing such impacts. "For example, when looking at greenhouse gas emissions the key is to determine the total amount of emissions being vented into the atmosphere," McKone said. "However, when looking at the release of toxic pollutants, where the pollutants are being released can be more important than how much or even how toxic." In preparing this LCIA on reduced gasoline use one of the biggest challenges faced by McKone and Lobscheid was the uncertainty factor in quantity, quality and relevance of their input data. "Uncertainty was the elephant in the room for us," McKone said. "For an LCIA there are two types of uncertainties, those due to variability in measurements and models, and those due to lack of knowledge. In our case, the data is not what we would like and it will take years to improve it." Nonetheless, McKone and Lobscheid were able to prepare an LCIA for reduced gasoline use based on the damage to human health that emissions from gasoline burning can cause. For a baseline, they used a 10-percent reduction in gasoline use. In assessing the impact of these emissions on human health they looked at "disability adjusted life years or "DALYs," which is a combination of two common damage factors in LCIAs - years of life lost due to premature mortality (YLLs) and the equivalent years of life lost due to disability (YLDs). One DALY is equal to one lost year of "healthy" life. To put this into perspective, the total annual disease burden in the United States is about 30 million DALYs. "In looking at emission impacts on health. we have the capacity to carry out county-level resolution measurements for both direct and indirect emissions," said McKone in his SIM symposium presentation. Measured emissions at county-level resolution included direct particulate matter and indirect fine particles (2.5 micrometers in diameter or smaller) produced from emissions of sulfate and nitrite gases, volatile organic compounds and ammonia, plus ozone, toxic air pollutants, emissions to surface and ground water, and emissions to soil. "We found that for the vehicle operation phase of our LCIA, the annual health damages avoided in the U.S. with 10-percent less gasoline-run motor vehicle emissions ranges from about 5,000 to 20,000 DALY, with most of the damage resulting from primary fine particle emissions," said McKone. "While county-specific damages range over nine orders of magnitude across all U.S. counties most of the damage, as you would expect, is concentrated in urban populations with the highest impact in the Los Angeles, New York and Chicago regions." Large urban regions also suffered disproportionate health damage as a result of benzene emissions at service stations and during the transporting by truck of gasoline to service stations - approximately 930 DALYs. "We need finer spatial resolution about the impacts and more data on emissions factors, even for gasoline, to remove some of the key uncertainties about how fuel switching plays," said McKone, "but clearly impacts on human health should be a prime consideration in future fuel policy decisions." Lynn Yarris DOE/Lawrence Berkeley National Laboratory


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