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Acting Surgeon General Issues 'Call To Action To Promote Healthy Homes'
Acting Surgeon General Steven K. Galson, M.D., M.P.H., issued The Surgeon General"s Call to Action to Promote Healthy Homes at a press conference from the National Building Museum in Washington D.C. The Call to Action looks at the ways housing can affect health; its release will initiate a national dialogue about the importance of healthy homes.

IQ Explains Some Of The Difference In Heart Disease Between People Of High And Low Socio-economic Status
A unique study looking at the difference in cardiovascular disease (heart disease and stroke) and life expectancy between people of high and low socio-economic status has found that a person"s IQ may have a role to play.
News of the day
FDA Adds Strong Warnings To Anti-Smoking Drug Labels
"The Food and Drug Administration announced (Wednesday) that it is requiring the smoking-cessation drugs Chantix and Zyban to carry the strongest type of safety warning possible to alert patients that the medications can cause serious mental health problems, including depression and suicide," the Washington Post reports (Stein, 7/1).
Cardiovascular

The Protein CCKR2: A Potential Drug Target For Colorectal Cancer?

Colorectal cancer, the second most common cause of death from cancer in the United States, is associated with an abnormally high rate of increase in the number of cells lining the colon (colonic hyperproliferation). In mice, overexpression of the human protein progastrin has been shown to cause colonic hyperproliferation and promote colorectal cancer, but the molecular mechanisms underlying this have remained undetermined. In a new study, Timothy Wang and colleagues, at Columbia University Medical Center, New York, have revealed a key link between the protein CCKR2 and progastrin-related colonic hyperproliferation. Initial analysis indicated that the Cck2r gene was upregulated in mice that overexpressed human progastrin. Deletion of this gene in mice that overexpressed human progastrin abolished the colonic hyperproliferation induced by the high levels of human progastrin and markedly diminished the extent of experimentally induced colorectal cancer. As previously published data indicate that levels of progastrin might be elevated in individuals with colorectal cancer, the authors conclude that their study suggests that CCKR2 may be a viable target for the development of drugs to treat or prevent colorectal cancer. TITLE: Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice AUTHOR CONTACT: Timothy C. Wang Columbia University Medical Center, New York, New York, USA PDF of this article. Karen Honey Journal of Clinical Investigation


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