Popular Articles

Serum Bile Acid Profiling For Inflammatory Bowel Disease Characterization
Based on serum bank material, BA profiling was applied in IBD patients and healthy controls which showed that most but not all BA species were decreased to a different extent in CD and UC. BA decreases were highly pronounced in CD patients with surgical interventions in the gut. On the other hand, UC patients with additional liver and gallbladder diseases showed clearly increased levels of those BAs that are synthesized directly in the liver (primary BAs), or subsequently modified by intestinal bacteria (secondary BAs). Furthermore, a marked decrease in the toxic BA lithocholic acid (LCA) was found together with a marked increase in its physiological detoxification product, hyodeoxycholic acid (HDCA), irrespective of the IBD phenotype or clinical manifestation, which showed accelerated detoxification activity in IBD patients. Thus, serum BA profiling might serve as an additional diagnostic tool for IBD characterization and differentiation. In combination with expression profiles of nuclear pregnane X receptor (PXR)-regulated genes, it might allow us to estimate the BA detoxification potential of IBD patients.

Obesity Is A Problem For Dogs, Too!
It"s not just humans that suffer from obesity - vets say that emerging obesity problems in dogs are leading to shorter lives and reduced quality of life.
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Calling Everyone With Type 2 Diabetes, UK
Diabetes UK is looking for people with Type 2 diabetes to answer a quick and easy online survey about your experiences of hypoglycaemia ("hypos").
Public Health

"What Must EPS Pilot Prove?" Asks NPA

The NPA is asking its members to utilise the new NPA IT forums website to comment on the criteria that should be used to demonstrate that EPS is operationally functional ahead of national roll-out. The NPA believes that EPS must work technically, be business and operationally functional, improve service delivery at pharmacies, and is safe for patients, before full roll-out can be contemplated. The website, http://itforums.npa.co.uk, provides an opportunity for members throughout the UK to voice their opinions on the IT programmes affecting their country or on general IT topics which affect all nations. Gareth Jones, NPA NHS Liaison Manager said: "The NPA is playing an active role in shaping the development of how pharmacy IT programmes will roll out. The IT forums website, we hope, will stimulate debate and give us another way of collecting members" views and concerns about the new programmes being implemented." "We would like active discussion from members on EPS in England, EPES in Northern Ireland, the epharmacy programme in Scotland and 2DRx in Wales. It is important to recognise that effective IT will be increasingly important if community pharmacy is going to meet its future challenges. The NPA has used the forum to re-state its position on EPS and in the next few weeks will be adding EPS dispensary workflows for debate, and asking participants about how they would like to see PMR systems develop. The NPA wants to encourage dialogue on what all these issues will mean for the pharmacist and the pharmacy team and this website provides a platform for that." National Pharmacy Association


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